Cyclopropylamine → N-Cyclopropyl-2-{4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetamide

HRID 1778709Notes

Reaction equation

HRID 1778709 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([OH:30])=O)[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1.[CH:31]1([NH2:34])[CH2:33][CH2:32]1>>[CH:31]1([NH:34][C:28](=[O:30])[CH2:27][N:25]2[CH:26]=[C:22]([C:19]3[C:16]4[CH:17]=[N:18][C:13]([C:3]5[C:2]([Cl:1])=[C:7]([O:8][CH3:9])[CH:6]=[C:5]([O:10][CH3:11])[C:4]=5[Cl:12])=[CH:14][C:15]=4[NH:21][N:20]=3)[CH:23]=[N:24]2)[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 86722827{4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid

Product 1

HCID 76285268N-Cyclopropyl-2-{4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetamide

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 36, Step 2, starting from {4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid and cyclopropylamine. LCMS (M+H)+=487.1/489.1.

Workup

  1. customThis compound was prepared
  2. customthose described for the synthesis of Example 36, Step 2

Sources & evidence

ORD record
ord-63588b317b764aaa9a635293a7a7745b
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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