Morpholine → 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-3-[1-(2-morpholin-4-yl-2-oxoethyl)-1H-pyrazol-4-yl]-1H-pyrazolo[4,3-c]pyridine

HRID 1778711Notes

Reaction equation

HRID 1778711 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([OH:30])=O)[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)=[O:30])[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 86722827{4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid

Product 1

HCID 762852676-(2,6-Dichloro-3,5-dimethoxyphenyl)-3-[1-(2-morpholin-4-yl-2-oxoethyl)-1H-pyrazol-4-yl]-1H-pyrazolo[4,3-c]pyridine

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 36, Step 2, starting from {4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid and morpholine. LCMS (M+H)+=517.0/519.0.

Workup

  1. customThis compound was prepared
  2. customthose described for the synthesis of Example 36, Step 2

Sources & evidence

ORD record
ord-4ddc94d7ef6e49df9fc8dd1cc639ac64
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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