4-Hydroxypyrrolidine → HCID 76285300, compound

HRID 1778714Notes

Reaction equation

HRID 1778714 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([OH:30])=O)[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1.[NH:31]1[CH2:35][CH2:34][CH:33]([OH:36])[CH2:32]1>>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([N:31]4[CH2:35][CH2:34][CH:33]([OH:36])[CH2:32]4)=[O:30])[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 86722827{4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid

Product 1

HCID 76285300HCID 76285300, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 36, Step 2, starting from {4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid and 3-pyrrolidinol. LCMS (M+H)+=517.1/519.0.

Workup

  1. customThis compound was prepared
  2. customthose described for the synthesis of Example 36, Step 2

Sources & evidence

ORD record
ord-1a0b36aa8a564434a0fc1889fa6324d6
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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