3-Methoxypyrrolidine → HCID 76285393, compound

HRID 1778716Notes

Reaction equation

HRID 1778716 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([OH:30])=O)[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1.[CH3:31][O:32][CH:33]1[CH2:37][CH2:36][NH:35][CH2:34]1>>[Cl:12][C:4]1[C:5]([O:10][CH3:11])=[CH:6][C:7]([O:8][CH3:9])=[C:2]([Cl:1])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([N:35]4[CH2:36][CH2:37][CH:33]([O:32][CH3:31])[CH2:34]4)=[O:30])[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 113554473-MethoxypyrrolidineHCID 86722827{4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid

Product 1

HCID 76285393HCID 76285393, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 36, Step 2, starting from {4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid and 3-methoxypyrrolidine. LCMS (M+H)+=531.2/533.2.

Workup

  1. customThis compound was prepared
  2. customthose described for the synthesis of Example 36, Step 2

Sources & evidence

ORD record
ord-abb72df6981d408a8461b8a009b39a35
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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