Pyrrolidine-3-carbonitrile hydrochloride → 1-({4-[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetyl)pyrrolidine-3-carbonitrile

HRID 1778718Notes

Reaction equation

HRID 1778718 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28](O)=[O:29])[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1.Cl.[NH:32]1[CH2:36][CH2:35][CH:34]([C:37]#[N:38])[CH2:33]1>>[Cl:12][C:4]1[C:5]([O:10][CH3:11])=[CH:6][C:7]([O:8][CH3:9])=[C:2]([Cl:1])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][C:28]([N:32]4[CH2:36][CH2:35][CH:34]([C:37]#[N:38])[CH2:33]4)=[O:29])[CH:26]=3)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 42614784Pyrrolidine-3-carbonitrile hydrochlorideHCID 86722827{4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid

Product 1

HCID 762853961-({4-[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetyl)pyrrolidine-3-carbonitrile

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 36, Step 2, starting from {4-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-1H-pyrazol-1-yl}acetic acid and pyrrolidine-3-carbonitrile hydrochloride. LCMS (M+H)+=526.2/528.1.

Workup

  1. customThis compound was prepared
  2. customthose described for the synthesis of Example 36, Step 2

Sources & evidence

ORD record
ord-6ab41d079aa3476fba43b8d5f1bc14c5
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

Loading…