反应详情

1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate (97 mg, 0.27 mmol) was added a stirring solution of 6-(2-fluoro-3,5-dimethoxyphenyl)-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine (88 mg, 0.18 mmol) in acetonitrile (5 mL). The mixture was stirred at r.t. for 1 h then concentrated. The solid was filtered out and the filtrate was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-50%) to afford the desired product (30 mg). LCMS (M+H)+=502.0.

1. concentrationthen concentrated
2. filtrationThe solid was filtered out
3. customthe filtrate was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-50%)