2-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one → HCID 76284843, compound

HRID 1778737Notes

Reaction equation

HRID 1778737 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19](I)=[N:20][N:21](C3CCCCO3)[C:15]=2[CH:14]=1.[CH:29]1([N:32]2[CH2:40][C:39]3[C:34](=[CH:35][CH:36]=[C:37](B4OC(C)(C)C(C)(C)O4)[CH:38]=3)[C:33]2=[O:50])[CH2:31][CH2:30]1>>[CH:29]1([N:32]2[CH2:40][C:39]3[C:34](=[CH:35][CH:36]=[C:37]([C:19]4[C:16]5[CH:17]=[N:18][C:13]([C:3]6[C:2]([F:1])=[C:7]([O:8][CH3:9])[CH:6]=[C:5]([O:10][CH3:11])[C:4]=6[F:12])=[CH:14][C:15]=5[NH:21][N:20]=4)[CH:38]=3)[C:33]2=[O:50])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 594023502-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-oneHCID 86722838HCID 86722838, compound

Product 1

HCID 76284843HCID 76284843, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 8 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine and 2-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one (Example 21, Step 2) LCMS (M+H)+=463.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-93bbab7bb2ee4a73a5cbd9ecb7bbc1cc
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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