HCID 86722838, compound → HCID 76284886, compound

HRID 1778743Notes

Reaction equation

HRID 1778743 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19](I)=[N:20][N:21](C3CCCCO3)[C:15]=2[CH:14]=1.ClC1C(OC)=CC(OC)=C(Cl)C=1C1N=C2NN=C([C:50]3[CH:51]=[C:52]4[C:57](=[CH:58][CH:59]=3)[O:56][CH:55]([C:60]([N:62]([CH3:64])[CH3:63])=[O:61])[CH2:54][CH2:53]4)C2=CN=1>>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:50]3[CH:51]=[C:52]4[C:57](=[CH:58][CH:59]=3)[O:56][CH:55]([C:60]([N:62]([CH3:64])[CH3:63])=[O:61])[CH2:54][CH2:53]4)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 86722838HCID 86722838, compoundHCID 178493465HCID 178493465, compound

Product 1

HCID 76284886HCID 76284886, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 8 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine and N,N-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chromane-2-carboxamide (Example 2, Step 2). LCMS (M+H)+=495.4.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-53e45cc4e2d04586a210034ae64c67ff
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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