HCID 86722838, compound → HCID 76284841, compound

HRID 1778747Notes

Reaction equation

HRID 1778747 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19](I)=[N:20][N:21](C3CCCCO3)[C:15]=2[CH:14]=1.[O:29]1[CH2:34][CH2:33][CH:32]([N:35]2[CH2:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40](B4OC(C)(C)C(C)(C)O4)[CH:41]=3)[C:36]2=[O:53])[CH2:31][CH2:30]1>>[F:12][C:4]1[C:5]([O:10][CH3:11])=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:40]3[CH:41]=[C:42]4[C:37](=[CH:38][CH:39]=3)[C:36](=[O:53])[N:35]([CH:32]3[CH2:33][CH2:34][O:29][CH2:30][CH2:31]3)[CH2:43]4)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 86722838HCID 86722838, compoundHCID 867228442,3-Dihydro-2-(tetrahydro-2H-pyran-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-isoindol-1-one

Product 1

HCID 76284841HCID 76284841, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 8 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine and 2-(tetrahydro-2H-pyran-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one. LCMS (M+H)+=507.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-4797525b037147cb856673d4a3502dac
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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