Ethanamine, 2,2,2-trifluoro- → 5-Bromo-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-isoindol-1-one

HRID 1778748Notes

Reaction equation

HRID 1778748 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O-:8])=O)=[C:4]([CH2:11]Br)[CH:3]=1.[F:13][C:14]([F:18])([F:17])[CH2:15][NH2:16]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[N:16]([CH2:15][C:14]([F:18])([F:17])[F:13])[CH2:11]2

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 231581454-Bromo-2-(bromomethyl)benzoate

Product 1

HCID 594207555-Bromo-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-isoindol-1-one

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 6 starting from 4-bromo-2-(bromomethyl)benzoate and 2,2,2-trifluoroethylamine (Aldrich Cat No. 269042). LCMS (M+H)+=294.0/296.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-99693621b31247d081a8124222989e18
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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