HCID 86722838, compound → HCID 76284934, compound

HRID 1778749Notes

Reaction equation

HRID 1778749 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19](I)=[N:20][N:21](C3CCCCO3)[C:15]=2[CH:14]=1.CC1(C)C(C)(C)OB([C:37]2[CH:38]=[C:39]3[C:43](=[CH:44][CH:45]=2)[C:42](=[O:46])[N:41]([CH2:47][C:48]([F:51])([F:50])[F:49])[CH2:40]3)O1>>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:37]3[CH:38]=[C:39]4[C:43](=[CH:44][CH:45]=3)[C:42](=[O:46])[N:41]([CH2:47][C:48]([F:51])([F:50])[F:49])[CH2:40]4)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 86722838HCID 86722838, compoundHCID 86722845HCID 86722845, compound

Product 1

HCID 76284934HCID 76284934, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 8 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethyl)isoindolin-1-one. LCMS (M+H)+=505.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3cd9ad8c188e42559b66e0fdda2567ad
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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