HCID 86722838, compound → HCID 76284794, compound

HRID 1778757Notes

Reaction equation

HRID 1778757 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19](I)=[N:20][N:21](C3CCCCO3)[C:15]=2[CH:14]=1.[F:29][C:30]1[CH:38]=[C:37]2[C:33]([CH2:34][N:35]([CH:40]([CH3:42])[CH3:41])[C:36]2=[O:39])=[CH:32][C:31]=1B(O)O>>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:31]3[CH:32]=[C:33]4[C:37](=[CH:38][C:30]=3[F:29])[C:36](=[O:39])[N:35]([CH:40]([CH3:42])[CH3:41])[CH2:34]4)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

3

Reactant 2

HCID 86722838HCID 86722838, compoundHCID 86722853HCID 86722853, compound

Product 1

HCID 76284794HCID 76284794, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 8 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine and (6-fluoro-2-isopropyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)boronic acid. LCMS (M+H)+=483.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-51caf293342a4d8c877550daa1387322
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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