HCID 86722838, compound → HCID 76284888, compound

HRID 1778763Notes

Reaction equation

[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19](I)=[N:20][N:21](C3CCCCO3)[C:15]=2[CH:14]=1.[CH3:29][N:30]1[CH2:34][CH2:33][CH2:32][CH:31]1[CH2:35][CH2:36][N:37]1[CH2:45][C:44]2[C:39](=[CH:40][CH:41]=[C:42](B3OC(C)(C)C(C)(C)O3)[CH:43]=2)[C:38]1=[O:55]>>[F:12][C:4]1[C:5]([O:10][CH3:11])=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[C:3]=1[C:13]1[N:18]=[CH:17][C:16]2[C:19]([C:42]3[CH:43]=[C:44]4[C:39](=[CH:40][CH:41]=3)[C:38](=[O:55])[N:37]([CH2:36][CH2:35][CH:31]3[CH2:32][CH2:33][CH2:34][N:30]3[CH3:29])[CH2:45]4)=[N:20][NH:21][C:15]=2[CH:14]=1

Participants

Reactant 2

HCID 86722838HCID 86722838, compound

HCID 86722859HCID 86722859, compound

Product 1

HCID 76284888HCID 76284888, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 8 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine and 2-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one. LCMS (M+H)+=534.3.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-4b6f9304be964fa69896320479919b74
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09266892B2

Reaction notes

Loading…