HCID 86722847, compound → HCID 178493507, compound

HRID 1778783Notes

Reaction equation

HRID 1778783 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21](I)[C:16]2=[CH:15][N:14]=1.[OH:23][CH2:24][CH:25]([N:27]1[CH2:35][C:34]2[C:29](=[CH:30][CH:31]=[C:32](B3OC(C)(C)C(C)(C)O3)[CH:33]=2)[C:28]1=[O:45])[CH3:26]>>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21]([C:32]3[CH:33]=[C:34]4[C:29](=[CH:30][CH:31]=3)[C:28](=[O:45])[N:27]([CH:25]([CH3:26])[CH2:24][OH:23])[CH2:35]4)[C:16]2=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 86722847HCID 86722847, compoundHCID 178493522HCID 178493522, compound

Product 1

HCID 178493507HCID 178493507, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 4, Step 2 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and 2-(2-hydroxy-1-methylethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one. LCMS (M+H)+=482.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-82568439ce2348148dc319992c1589da
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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