HRID1778793

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16217660

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

C14H21BO4

结构：O=C1c2ccc(-c3nn(C4CCCCO4)c4nc(Cl)ccc34)cc2CN1C1CC1

HCID86722872

未命名化合物

PRODUCTS

生成物

结构：COc1cc(OC)cc(-c2ccc3c(-c4ccc5c(c4)CN(C4CC4)C5=O)nn(C4CCCCO4)c3n2)c1

HCID86722873

未命名化合物

PROCEDURE

实验过程

This compound was prepared by using procedures analogous to those described for the synthesis of Example 72, Step 4 starting from 5-[6-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-cyclopropylisoindolin-1-one and 2-(3,5-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. LCMS (M+H)+=511.2.

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e699676f549d4fdaa03606b43d2e04cc
来源数据集: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09266892B2
来源说明: uspto-grants-2016_02

反应 SMILES

Cl[C:2]1[N:7]=[C:6]2[N:8]([CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][O:25]3)[N:9]=[C:10]([C:11]3[CH:12]=[C:13]4[C:17](=[CH:18][CH:19]=3)[C:16](=[O:20])[N:15]([CH:21]3[CH2:23][CH2:22]3)[CH2:14]4)[C:5]2=[CH:4][CH:3]=1.[CH3:30][O:31][C:32]1[CH:33]=[C:34](B2OC(C)(C)C(C)(C)O2)[CH:35]=[C:36]([O:38][CH3:39])[CH:37]=1>>[CH:21]1([N:15]2[CH2:14][C:13]3[C:17](=[CH:18][CH:19]=[C:11]([C:10]4[C:5]5[C:6](=[N:7][C:2]([C:34]6[CH:33]=[C:32]([O:31][CH3:30])[CH:37]=[C:36]([O:38][CH3:39])[CH:35]=6)=[CH:3][CH:4]=5)[N:8]([CH:24]5[CH2:29][CH2:28][CH2:27][CH2:26][O:25]5)[N:9]=4)[CH:12]=3)[C:16]2=[O:20])[CH2:23][CH2:22]1