Imidazo[1,2-a]pyridin-6-ylboronic acid → HCID 178493515, compound

HRID 1778802Notes

Reaction equation

HRID 1778802 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21](I)[C:16]2=[CH:15][N:14]=1.[N:23]1[CH:24]=[CH:25][N:26]2[CH:31]=[C:30](B(O)O)[CH:29]=[CH:28][C:27]=12>>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21]([C:30]3[CH:29]=[CH:28][C:27]4[N:26]([CH:25]=[CH:24][N:23]=4)[CH:31]=3)[C:16]2=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 44119340Imidazo[1,2-a]pyridin-6-ylboronic acidHCID 178493522HCID 178493522, compound

Product 1

HCID 178493515HCID 178493515, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 4, Step 2 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine (16.7 mg, 0.0400 mmol)(Example 3, Step 4) and imidazo[1,2-a]pyridin-6-ylboronic acid (Combi-Blocks, Cat. No. BB-3457). LCMS (M+H)+=409.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-547fd7833eb64ee686bd9b072921b8fd
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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