Quinolin-6-ylboronic Acid (contains varying amounts of Anhydride) → HCID 178493514, compound

HRID 1778803Notes

Reaction equation

HRID 1778803 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21](I)[C:16]2=[CH:15][N:14]=1.[N:23]1[C:32]2[C:27](=[CH:28][C:29](B(O)O)=[CH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=1>>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([F:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21]([C:29]3[CH:28]=[C:27]4[C:32](=[CH:31][CH:30]=3)[N:23]=[CH:24][CH:25]=[CH:26]4)[C:16]2=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 4192671Quinolin-6-ylboronic Acid (contains varying amounts of Anhydride)HCID 178493522HCID 178493522, compound

Product 1

HCID 178493514HCID 178493514, compound

Procedure

This compound was prepared using procedures analogous to those described for the synthesis of Example 4, Step 2 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and quinolin-6-ylboronic acid (Combi-Blocks, Cat. No. BB-5182). LCMS (M+H)+=420.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-9460bc0e99e74911bdedf07f50033f6b
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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