Sodium Hydroxide → HCID 66024353, compound

HRID 1778854Notes

Reaction equation

HRID 1778854 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1([C:12](OC)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>C(OCC)C>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:12][OH:13])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 86681305HCID 86681305, compound

Product 1

HCID 66024353HCID 66024353, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Conditions

Temperature
0 °C

Procedure

A solution of EXAMPLE 97A (2.14 g) in diethyl ether (10 mL) was added dropwise to a suspension of LiAlH4 (0.380 g) in diethyl ether (20 mL). Once the addition was finished, the mixture was refluxed for 90 minutes, and then cooled to 0° C. NaOH (2N, aqueous, 50 mL) was then added slowly. The mixture was extracted with ethyl acetate (300 mL) and washed with brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.

Workup

  1. additionOnce the addition
  2. temperaturethe mixture was refluxed for 90 minutes
  3. extractionThe mixture was extracted with ethyl acetate (300 mL)
  4. washwashed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationFiltration and evaporation of the solvent

Sources & evidence

ORD record
ord-4456eadb49ff40a8a37bd753e913d4c0
Source dataset
uspto-grants-2016_02
Patent number
US09266877B2

Reaction notes

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