反应详情

LiOH (69.0 mg, 2.86 mmol) was added to a solution of methyl 2-(2-(2-(2-(4-(1-(tert-butoxycarbonylamino)ethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate (A65) (320 mg, 0.573 mmol) in THF (7.5 mL) and water (2.5 mL) and the resulting mixture stirred at room temperature overnight. The resulting mixture was evaporated in vacuo then the residue was partitioned between EtOAc (15 mL) and 1 M aqueous HCl. The phases were separated and the aqueous phase was extracted with EtOAc. The combined organic phases were washed with brine, dried with Na2SO4 and concentrated to give the title compound A66 (310 mg, 99%); LCMS-B: rt 8.30 min; m/z 545.4 [M+H]+.

1. customThe resulting mixture was evaporated in vacuo
2. customthe residue was partitioned between EtOAc (15 mL) and 1 M aqueous HCl
3. customThe phases were separated
4. extractionthe aqueous phase was extracted with EtOAc
5. washThe combined organic phases were washed with brine
6. dry with materialdried with Na2SO4
7. concentrationconcentrated