Anisole → HCID 90060127, compound

Participants

Reaction Steps

Formic acid (5 mL), and anisole (20 μL) were added to tert-butyl (S)-2-amino-3-(4-but-2-ynyloxy-phenyl)-propionate HCl salt (200 mg) and the mixture was stirred at room temperature for 18 hours. Completion of the reaction was confirmed by detecting the target product by LCMS (LCMS m/z 234 (M+1), Rt 0.83 min.). The reaction solution was concentrated under reduced pressure to obtain (S)-2-amino-3-(4-but-2-ynyloxy-phenyl)-propionic acid (186 mg).

Provenance & Evidence