Trifluoroacetic acid methylene chloride → HCID 118260143, compound

Participants

Reaction Steps

To No. 5214357, (E)-(2S,3S)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-2-hydroxy-2-(2-hydroxy-ethyl)-12-oxo-nonadec-4-enoic acid (20 mg, 0.0310 mmol) was added a mixture of dichloromethane/trifluoroacetic acid (9/1, v/v, 2 mL) and the mixture was stirred at room temperature for 1 hour. After confirming the consumption of the starting materials by LCMS, the organic solvent was distilled off under reduced pressure. The resulting residue was purified by preparative HPLC and then freeze-dried to obtain No. 5214805 (11 mg, 56% yield, white powder).

Provenance & Evidence