HCID 90060183, compound → HCID 90060253, compound

Participants

Reaction Steps

An intermediate, tert-butyl (E)-(2S,3S)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-hydroxymethyl-ethylcarbamoyl]-11-(2-heptyl-[1,3]dioxolan-2-yl)-2-hydroxy-undec-4-enoate (ESI (LC/MS positive mode) m/z 831 (M+H); Rt 3.98 min.) was synthesized by the synthetic method similar to that of No. 5327507, tert-butyl (E)-(2S,3S)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-11-(2-heptyl-[1,3]dioxolan-2-yl)-2-hydroxy-undec-4-enoate, except that (S)-2-amino-3-(4-but-2-ynyloxy-phenyl)-propan-1-ol hydrochloride was used instead of methyl (S)-2-amino-3-(4-but-2-ynyloxy-phenyl)-propionate hydrochloride. From the obtained intermediate, No. 6801976 (ESI (LC/MS positive mode) m/z 672 (M+H); Rt 2.70 min.) was synthesized by a synthetic method similar to that of No. 5217614, tert-butyl (E)-(2S,3S)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-2-hydroxy-2-(2-hydroxy-ethyl)-12-oxo-nonadec-4-enoate.

Provenance & Evidence