Methanol → HCID 118157636, compound

Participants

Reaction Steps

To a mixture of No. 5257015 , (E)-(2S,3S)-2-(2-acetoxy-ethyl)-3-[(S)-1-acetoxymethyl-2-(4-but-2-ynyloxy-phenyl)-ethylcarbamoyl]-2-hydroxy-12-oxo-nonadec-4-enoic acid (17 mg, 0.0244 mmol) and methanol (1.7 mL) were added water (49 μL) and LiOH (2.4 mg, 0.0983 mmol), and the mixture was stirred at room temperature. After confirming the consumption of the starting materials by LCMS, the reaction solution was purified directly by preparative HPLC, and freeze-dried to obtain the title compound (9 mg, 60% yield, yellow oil).

Provenance & Evidence