HCID 54673085, compound → HCID 90060259, compound

Participants

Reaction Steps

No. 6801995, methyl (S)-2-[(E)-(S)-2-((S)-3-acetoxy-1-carbamoyl-1-hydroxy-propyl)-11-oxo-octadec-3-enoylamino]-3-(4-but-2-ynyloxy-phenyl)-propionate (ESI (LC/MS positive mode) m/z 685 (M+H); Rt 3.40 min.) was synthesized by the synthesis similar to that of No. 5453635, 2-cyclohexyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-hydroxy-1,2-dimethyl-propyl)-amide, except that No. 5214354, (E)-(2S,3S)-2-(2-acetoxy-ethyl)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-2-hydroxy-12-oxo-nonadec-4-enoic acid was used instead of No. 5317776, 1-tert-butyl (S)-2-{(E)-(S)-1-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-10-oxo-heptadec-2-enyl}-2-hydroxy-succinate. From methyl (S)-2-[(E)-(S)-2-((S)-3-acetoxy-1-carbamoyl-1-hydroxy-propyl)-11-oxo-octadec-3-enoylamino]-3-(4-but-2-ynyloxy-phenyl)-propionate, the title compound was obtained by the synthesis by a synthetic method similar to that of No. 5257016, (E)-(2S,3S)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-hydroxymethyl-ethylcarbamoyl]-2-hydroxy-2-(2-hydroxy-ethyl)-12-oxo-nonadec-4-enoic acid.

Provenance & Evidence