Methanol → HCID 118157463, compound

Participants

Reaction Steps

To a mixture of No. 5286993, potassium (E)-(2S,3S)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-2,12-dihydroxy-2-(2-hydroxy-ethyl)-nonadec-4-enoate (40 mg, 0.0584 mmol) and methanol (2.0 mL) were added water (2.0 mL) and potassium carbonate (40 mg, 0.146 mmol), and the mixture was stirred at room temperature for 4 hours. After confirming the consumption of the starting materials by LCMS, water was added and the mixture was extracted with ethyl acetate. To the aqueous layer was then added 1 M hydrochloric acid until pH 7 was reached. The organic layer was washed with a saturated brine, and dried over anhydrous sodium sulfate. The filtrate was then concentrated under reduced pressure to obtain the title compound (15 mg, 41% yield, white solid).

Provenance & Evidence