methyl (S)-2-amino-3-(4-butoxy-phenyl)-propionate → (E)-(2S,3S)-3-[(S)-2-(4-Butoxy-phenyl)-1-carboxy-ethylcarbamoyl]-2-(2,2-difluoro-ethyl)-2-hydroxy-12-oxo-nonadec-4-enoic acid

Participants

Reaction Steps

The title compound was synthesized by a method similar to that of No. 5509214, (E)-(2S,3S)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-2-(2,2-difluoro-ethyl)-2-hydroxy-12-oxo-nonadec-4-enoic acid, except that tert-butyl (S)-2-amino-3-(4-butoxy-phenyl)-propionate was used instead of No. 5509214, methyl (S)-2-amino-3-(4-butoxy-phenyl)-propionate.

Provenance & Evidence