Trifluoroacetic acid → HCID 118157745, compound

Participants

Reaction Steps

tert-Butyl (E)-(2S,3S)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-2-hydroxy-10-(octane-1-sulfonylamino)-2-propyl-dec-4-enoate (35.0 mg, 0.0467 mmol) was dissolved in dichloromethane (1.0 mL), and trifluoroacetic acid (1.0 mL, 13.6 mmol) was then added at room temperature. The mixture was stirred for 75 minutes, and then concentrated under reduced pressure. The resulting crude product was purified by preparative HPLC to obtain 29.1 mg (0.0420 mmol, 90% yield) of the title compound.

Provenance & Evidence