(S)-2-Amino-3-(4-but-2-ynyloxy-phenyl)-N-methyl-propionamide hydrochloride → (S)-2-amino-3-(4-butoxy-phenyl)-N-methyl-propionamide

Participants

Reaction Steps

(S)-2-Amino-3-(4-but-2-ynyloxy-phenyl)-N-methyl-propionamide hydrochloride (2.00 g, 7.07 mmol) was dissolved in methanol (100 mL), and Pd/C (230 mg) was then added at room temperature. After stirring for 17 hours under a hydrogen atmosphere, insoluble material was filtered off, and washed with methanol (3.0 mL). The filtrate was concentrated under reduced pressure, and then dissolved in ethyl acetate (150 mL). The solution was washed with sodium bicarbonate (100 mL) and a saturated aqueous solution (50 mL) of sodium chloride in this order, then dried over anhydrous sodium sulfate, and filtered. The solvent was distilled off under reduced pressure to obtain 1.77 g of the title compound (7.07 mmol, quant.).

Provenance & Evidence