Water → HCID 90060382, compound

Participants

Reaction Conditions

Reaction Steps

No. 5538573, (E)-(2S,3S)-12,12-difluoro-3-[(S)-2-(2′-fluoro-biphenyl-4-yl)-1-methoxycarbonyl-ethylcarbamoyl]-2-hydroxy-2-(2-methoxy-ethyl)-nonadec-4-enoic acid (8.2 mg, 0.0116 mmol) was dissolved in acetonitrile (0.328 mL), and water (0.0011 mL, 0.0611 mmol), triethylamine (0.0097 mL, 0.0696 mmol), and anhydrous lithium bromide (20.1 mg, 0.231 mmol) were then added at room temperature. The reaction mixture was stirred at 50° C. for 3.5 hours, cooled to room temperature, and then purified by preparative HPLC to obtain 6.7 mg of the title compound (0.00969 mmol, 83% yield).

Provenance & Evidence