methyl (S)-2-amino-3-(4-butoxy-phenyl)-propionate → tert-butyl (E)-(2S,3S)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-12,12-difluoro-2-hydroxy-2-(2-methoxy-ethyl)-nonadec-4-enoate

Participants

Reaction Steps

No. 6804236 was obtained by the synthetic method in Step A-4 (dehydration condensation with 1-[bis(dimethylamino)methyliumyl]-1H-1,2,3-triazolo[4,5-B]pyridine-3-oxide hexafluorophosphate), except that No. 5553644, 1-tert-butyl (2S,3S)-3-((E)-9,9-difluoro-hexadec-1-enyl)-2-hydroxy-2-(2-methoxy-ethyl)-succinate was used instead of No. 6801710, 1-tert-butyl (2S,3S)-3-[(E)-8-(2-heptyl-[1,3]dioxolan-2-yl)-oct-1-enyl]-2-hydroxy-2-(2-methoxy-ethyl)-succinate, and methyl (S)-2-amino-3-(4-butoxy-phenyl)-propionate was used instead of methyl (S)-2-amino-3-(4-but-2-ynyloxy-phenyl)-propionate.

Provenance & Evidence