Water → HCID 90060203, compound

Participants

Reaction Steps

(2S,3S,E)-tert-Butyl 3-((S)-3-(4-(but-2-ynyloxy)phenyl)-1-methoxy-1-oxopropan-2-ylcarbamoyl)-11-(2-heptyl-1,3-dioxolan-2-yl)-2-hydroxy-2-(2-methoxyethyl)-undec-4-enoate (1.619 g, 2.136 mmol) was dissolved in formic acid (8.0 mL), and water (420 μL) was added. The reaction mixture was stirred at room temperature for 24 hours, and concentrated. After subsequently repeating twice the operation of dissolution in ethyl acetate and concentration, the residue was purified by diol column chromatography (dichloromethane/ethyl acetate) to obtain the target compound at a yield of 80%.

Provenance & Evidence