Citric Acid → HCID 90060275, compound

Participants

Reaction Conditions

Reaction Steps

No. 5233427 (14.4 mg, 0.022 mmol) was dissolved in methanol (1.0 mL), and the solution was cooled to 0° C. in an ice bath. Sodium tetrahydroborate (5 mg, 0.13 mmol) was added, and the mixture was stirred for 3 hours. The progress of the reaction was stopped by adding water, and the mixture was diluted in ethyl acetate. An aqueous solution of 0.5 M citric acid was added and the mixture was separated. The separated organic layer was washed with water and a saturated brine in order, dried over anhydrous sodium sulfate, and then filtered. The filtrate was concentrated. The residue was purified by diol thin layer chromatography (dichloromethane:methanol=50 50) to obtain the target compound at a yield of 57%.

Provenance & Evidence