Water → HCID 90060337, compound

Participants

Reaction Steps

(2S,3S,E)-tert-Butyl 3-((S)-3-(4-(but-2-ynyloxy)phenyl)-1-methoxy-1-oxopropan-2-ylcarbamoyl)-11-(2-heptyl-1,3-dioxolan-2-yl)-2-hydroxy-2-methylundec-4-enoate (540 mg, 0.756 mmol) was dissolved in dichloromethane (3.5 mL), and water (0.35 mL) was added. Trifluoroacetic acid (10 mL) was added and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated. The residue was then purified by diol column chromatography (n-hexane/acetone) to obtain the target compound as pale yellow oil at a yield of 91%.

Provenance & Evidence