Citric Acid → HCID 90060384, compound

Participants

Reaction Steps

No. 5398770 (20 mg, 0.0326 mmol) was dissolved in methanol (0.4 mL), and an aqueous solution of 1 M sodium hydroxide (65 μL, 0.065 mmol) was added. The mixture was stirred at room temperature for 2 hours. To the resulting white suspension was added an aqueous solution of 0.5 M citric acid, and the mixture was extracted with ethyl acetate. The separated organic layer was washed twice with water, dried over anhydrous sodium sulfate, and then filtered. The filtrate was concentrated. The residue was purified by diol thin layer chromatography (dichloromethane/methanol) to obtain the target compound as clear and colorless solid at a yield of 70%.

Provenance & Evidence