反应详情

tert-Butyl [(S)-2-(4-but-2-ynyloxy-phenyl)-1-hydroxymethyl-ethyl]-carbamate (402 mg, 1.26 mmol) was dissolved in dichloromethane (6.3 mL), and acetic anhydride (0.179 mL, 1.89 mmol) and pyridine (204 μL, 2.52 mmol) were added at room temperature. The reaction mixture was stirred for 7 hours, then poured into a saturated brine, and extracted with ethyl acetate. The organic extract was dried over magnesium sulfate, and concentrated under reduced pressure to obtain the title compound (468 mg).

1. extractionextracted with ethyl acetate
2. extractionThe organic extract
3. dry with materialwas dried over magnesium sulfate
4. concentrationconcentrated under reduced pressure