Hydrogen chloride-ethyl acetate → HCID 118157652, compound

HRID 1779251Notes

Reaction equation

HRID 1779251 reaction equation
[C:1]([O:4][CH2:5][C@@H:6]([NH:19]C(OC(C)(C)C)=O)[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]#[C:17][CH3:18])=[CH:10][CH:9]=1)(=[O:3])[CH3:2].[ClH:27].C(OCC)(=O)C>>[ClH:27].[C:1]([O:4][CH2:5][C@@H:6]([NH2:19])[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:15][C:16]#[C:17][CH3:18])=[CH:12][CH:13]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 90060285HCID 90060285, compound

Product 1

HCID 118157652HCID 118157652, compound

Procedure

(S)-2-tert-Butoxycarbonylamino-3-(4-but-2-ynyloxy-phenyl)-propyl acetate was dissolved in a solution (3.0 mL) of 1 M hydrogen chloride/ethyl acetate, and the mixture was stirred at room temperature for 3 hours. The reaction mixture was then concentrated under reduced pressure to obtain the title compound.

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-b0708f351c6c49ad9541bf684c04493b
Source dataset
uspto-grants-2016_02
Patent number
US09266853B2

Reaction notes

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