2,6-Di-tert-butyl-4-methylpyridine → HCID 90060265, compound

Participants

Reaction Steps

tert-Butyl (E)-(2S,3S)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-dimethylcarbamoyl-ethylcarbamoyl]-2-hydroxy-2-(2-hydroxy-ethyl)-12-oxo-nonadec-4-enoate (15.0 mg, 21.5 μmol) was dissolved in dichloromethane (0.5 mL), and trimethyloxonium tetrafluoroborate (6.7 mg, 45.1 μmol) and 2,6-di-tert-butyl-4-methylpyridine (9.3 mg, 45.1 μmol) were added at 0° C. The mixture was stirred at room temperature for 5 hours. The reaction mixture was purified by preparative HPLC to obtain the title compound (3.5 mg, 22% yield).

Provenance & Evidence