HCID 90060443, compound → HCID 90060466, compound

HRID 1779258Notes

Reaction equation

HRID 1779258 reaction equation
C([O:4][CH2:5][CH2:6][C@:7]([OH:55])([C@@H:15]([C:33](=[O:54])[NH:34][C@H:35]([C:48]1[O:49][C:50]([CH3:53])=[CH:51][N:52]=1)[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([O:43][CH2:44][C:45]#[C:46][CH3:47])=[CH:39][CH:38]=1)/[CH:16]=[CH:17]/[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24](=[O:32])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:8]([O:10]C(C)(C)C)=[O:9])(=O)C>C(O)=O>[CH2:44]([O:43][C:40]1[CH:41]=[CH:42][C:37]([CH2:36][C@H:35]([NH:34][C:33]([C@@H:15](/[CH:16]=[CH:17]/[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24](=[O:32])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C@@:7]([OH:55])([CH2:6][CH2:5][OH:4])[C:8]([OH:10])=[O:9])=[O:54])[C:48]2[O:49][C:50]([CH3:53])=[CH:51][N:52]=2)=[CH:38][CH:39]=1)[C:45]#[C:46][CH3:47]

Participants

3

Reactant 1

HCID 90060443HCID 90060443, compound

Product 1

HCID 90060466HCID 90060466, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

tert-Butyl (E)-(2S,3S)-2-(2-acetoxy-ethyl)-3-[(S)-2-(4-but-2-ynyloxy-phenyl)-1-(5-methyl-oxazol-2-yl)-ethylcarbamoyl]-2-hydroxy-12-oxo-nonadec-4-enoate (4.0 mg) was dissolved in formic acid (0.5 mL), and the mixture was stirred at room temperature for 24 hours.

Sources & evidence

ORD record
ord-2af16240d10047e49de367f22a61504f
Source dataset
uspto-grants-2016_02
Patent number
US09266853B2

Reaction notes

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