Methanol → HCID 67878855, compound

HRID 1779296Notes

Reaction equation

HRID 1779296 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]2[C:3]=1[C:4]([C:14]1[N:19]=[C:18]([O:20][CH3:21])[CH:17]=[C:16]([O:22][CH3:23])[N:15]=1)([OH:13])[O:5][C:6]2=[O:7].CO.[CH:26]([NH2:29])([CH3:28])[CH3:27]>C(Cl)Cl>[CH:26]([NH3+:29])([CH3:28])[CH3:27].[Cl:1][C:2]1[C:3]([C:4]([C:14]2[N:15]=[C:16]([O:22][CH3:23])[CH:17]=[C:18]([O:20][CH3:21])[N:19]=2)=[O:13])=[C:8]([C:9]([Cl:12])=[CH:10][CH:11]=1)[C:6]([O-:7])=[O:5]

Participants

5

Reactant 3

HCID 887MethanolHCID 6363IsopropylamineHCID 11824456HCID 11824456, compound

Product 1

HCID 67878855HCID 67878855, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

24.13 g of 4,7-dichloro-3-(4,6-dimethoxy-2-pyrimidinyl)-3-hydroxyphthalide is slurried in 500 ml of methylene dichloride and 200 ml of methanol and 125 ml of freshly distilled isopropylamine added. The mixture is heated to reflux and the solution filtered, cooled and stripped. The solid is dried in vacuum for 4 hrs at 45° C. to give the title product m.p. 194°-196° C.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux
  3. filtrationthe solution filtered
  4. temperaturecooled
  5. customThe solid is dried in vacuum for 4 hrs at 45° C.

Sources & evidence

ORD record
ord-9e4184ef6db64d10afa3d97d9cef8983
Source dataset
uspto-grants-1997_05
Patent number
US05627138

Reaction notes

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