HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl hydroperoxide → N-methyl 3-phenyl-5-(4,6-dimethoxy-2-pyrimidinylcarbonyl)-4-isoxazolecarboxanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl hydroperoxide | HCID 6410 | — |
| Reactant | N-methyl 3-phenyl-5-(4,6-dimethoxy-2-pyrimidinylmethyl)-4-isoxazolecarboxanilide | HCID 19050670 | — |
| Catalyst | Dicobalt Octacarbonyl (stabilized with 1-5% Hexane) | HCID 25049 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-methyl 3-phenyl-5-(4,6-dimethoxy-2-pyrimidinylcarbonyl)-4-isoxazolecarboxanilide | HCID 19050660 | — |
Reaction Steps
A solution of 100 mg of N-methyl 3-phenyl-5-(4,6-dimethoxy-2-pyrimidinylmethyl)-4-isoxazolecarboxanilide, 20 mg of dicobalt octacarbonyl, and 1 ml of t-butylhydroperoxide, in 60 ml of acetonitrile is refluxed for 48 hours. An additional 1 ml of t-butylhydroperoxide is added after 12 hrs and 24 hrs. Thin layer chromatography after 48 hrs indicates the presence of starting material and the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05627137 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-3ba7d92dd7d940b8ab84a1d5c11cec22 |
| Source note | uspto-grants-1997_05 |