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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1779321Generated: October 29, 2026

4'-Hydroxyacetophenone → Ethyl 3-(4-hydroxyphenyl)-3-oxopropanoate

https://huagongshe.com/reaction/1779321

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4'-HydroxyacetophenoneHCID 7469—
ReactantDiethyl CarbonateHCID 7766—
ProductEthyl 3-(4-hydroxyphenyl)-3-oxopropanoateHCID 13136494—

Reaction Steps

This novel compound was synthesized by the acylation of 4-hydroxyacetophenone with diethylcarbonate to yield ethyl 4-hydroxybenzoylacetate. Treatment with acetic anhydride and subsequent catalytic hydrogenation yielded the desired product. The experimental details are given below:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05627165
Source datasetuspto-grants-1997_05
ORD IDord-e4a4879d36204848be077276ee41ef05
Source noteuspto-grants-1997_05