1H-1,2,4-Triazole → 1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

HRID 1779355노트

반응식

HRID 1779355 반응식
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9](Cl)=[O:10]>C(OCC)(=O)C>[F:6][C:7](=[C:12]([F:14])[F:13])[CH2:8][C:9]([N:1]1[CH:5]=[N:4][CH:3]=[N:2]1)=[O:10]

참가 물질

4

반응물 2

HCID 92571H-1,2,4-TriazoleHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

생성물 1

HCID 218364821-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole수율 94.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min end filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) end filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a clear oil.

후처리

  1. stirringThe mixture was stirred for 30 min end
  2. filtrationfiltered
  3. customThe residue obtained
  4. customafter evaporation of the solvent
  5. dissolutionwas redissolved in dichloromethane (25 mL) end
  6. filtrationfiltered
  7. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-7f91cbce116745c3b57a1eb0e93d9c0a
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05627174

반응 노트

불러오는 중…