HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl phosphite → Diethyl (2,3,3-trifluro-2propenyl)phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | 1-Propene, 3-bromo-1,1,2-trifluoro- | HCID 10631079 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Diethyl (1,1,2-trifluoro-2-propenyl)phosphonate | HCID 53986716 | 11% |
| Product | Diethyl (2,3,3-trifluro-2propenyl)phosphonate | HCID 54339468 | 14% |
Reaction Steps
A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonitrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluoro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluoro-2-propenyl)phosphonate (1.0 g, 14%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05627174 |
| Source dataset | uspto-grants-1997_05 |
| ORD ID | ord-74a3a865e2264160a27c8010e0b71b94 |
| Source note | uspto-grants-1997_05 |