HCID 178513051, compound → HCID 178513050, compound

HRID 1779363Notes

Reaction equation

HRID 1779363 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:19]=[C:18]([C:20]([NH:22][C:23]([NH2:25])=[NH:24])=[O:21])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[CH:19]=[C:18]([C:20]([NH:22][C:23]([NH2:25])=[NH:24])=[O:21])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 178513051HCID 178513051, compound

Product 1

HCID 178513050HCID 178513050, compoundYield 123.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-(3'-Nitrophenyl)quinoline-4-carbonylguanidine (0.40 g) formed in Example 19 was dissolved in 40 ml of methanol, and hydrogenated under normal pressure for 5.5 hours in the presence of 0.3 g of Pd/C (purity 10%). The catalyst was filtered off from the reaction solution, and the filtrate was concentrated to obtain 0.45 g of the above-mentioned compound as a brown crystal. m.p. 209°-210° C.

Workup

  1. filtrationThe catalyst was filtered off from the reaction solution
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-76fba918aa59402f84434d3aff7f0b89
Source dataset
uspto-grants-1997_05
Patent number
US05627193

Reaction notes

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