Acetic Acid → HCID 86750788, compound

Participants

Reaction Steps

A solution of the final product of Example 10 (0.19 g) in a mixture of acetic acid (8.3 ml) and water (3.7 mi) was heated at 95°-100° C. for 15 hours. The solvent was removed by evaporation under reduced pressure and the resulting residue was triturated with ethyl acetate (5 ml). The solid obtained was collected and dried in vacuo at 70° C. to give 2-ethyl-3-[2'-(2-hydroxy-3,4-dioxocyclobut-1-en-1-yl)biphenyl-4-ylmethyl]-5,7, N,N-tetramethyl-3H-imidazo[4,5-b]pyridine-6-sulphonamide mono-ethyl acetate solvate (0.15 g; m.p. 195°-197° C. (with decomposition)), an active compound of the present invention.

Provenance & Evidence