Butylamine → HCID 19955581, compound

Participants

Reaction Steps

A solution of 4-bromomethyl-2'-iodobiphenyl (4.0 g; preparable as in Example 2(b)) and butylamine (40 ml) in dry tetrahydrofuran (55 ml) was stirred for 18 hours an ambient temperature then boiled under reflux for 45 minutes. The solvent was evaporated under reduced pressure and the resulting residue was then dissolved in dichloromethane (100 ml) to give a solution which was washed with aqueous potassium hydroxide solution (1M; 2×50 ml), water (50 ml), then hydrochloric acid (5M; 2×50 ml), then organic layer was dried over magnesium sulphate and the organic solvent was evaporated. The residue obtained was purified by flash chromatography on silica gel (eluting with dichloromethane/methanol (9:1) to give the intermediate compound N-(2'-iodobiphenyl-4ylmethyl)butylamine (1.9 g; m.p. 134°-136° C.).

Provenance & Evidence