Acetone Cyanohydrin → 2-((4-Hydroxybutyl)amino)-2-methylpropanenitrile

HRID 1779474Notes

Reaction equation

HRID 1779474 reaction equation
[CH3:1][C:2]([CH3:6])(O)[C:3]#[N:4].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>C(Cl)Cl>[OH:12][CH2:11][CH2:10][CH2:9][CH2:8][NH:7][C:2]([CH3:6])([CH3:1])[C:3]#[N:4]

Participants

4

Reactant 2

HCID 6406Acetone CyanohydrinHCID 258684-Amino-1-butanol

Product 1

HCID 155119612-((4-Hydroxybutyl)amino)-2-methylpropanenitrile

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

220 μl of acetone cyanohydrin and 200 μl of 4-amino 1-butanol were mixed together with stirring for 16 hours at 20° C. and then was diluted with 2 ml of methylene chloride, dried, filtered and the filtrate was concentrated under reduced pressure to obtain the propanonitrile which was used as is for the following stage.

Workup

  1. customdried
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-87f3e3557c5846598fe8069a205aa350
Source dataset
uspto-grants-1997_05
Patent number
US05627201

Reaction notes

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