Hydroxyamine hydrochloride → HCID 73677881, compound

Participants

Reaction Steps

Add 3.9 g (56.1 mmol) of hydroxylamine hydrochloride to a solution of 4.6 g (22.6 mmol) of 7-chloropyrrolo[1,2-a]indol-9-one in 80 ml of pyridine, then heat the reaction mixture at reflux for 3 hours. After cooling, the pyridine is removed under reduced pressure and the residue is taken up in water and extracted with 300 ml of diethyl ether. The ethereal phase is washed with 100 ml of 0.5N hydrochloric acid and then with water, dried over magnesium sulfate, rendered colourless with animal charcoal and then concentrated under reduced pressure to yield 4.18 g of the title product.

Provenance & Evidence