1,2-Dichloroethane → HCID 22872485, compound

Participants

Reaction Conditions

Reaction Steps

N-[(tert-Butyloxy)carbonyl-3(S)-ethylpyrrolidin-2(S)-ylmethyl]-proline (0.238 mmol), HOBT (0.048 g, 0.262 mmol), EDC (0.068 g, 0.0357 mmol), and methionine methyl ester hydrochloride (0.048 g, 0.238 mmol) were dissolved in CH2CL2 (10 mL) and stirred at 23° C. for 18 h. EtOAc (100 mL) was added, and the mixture washed with satd NaHCO3 solution, H2O, brine, and dried (MgSO4). Filtration and concentration to dryness gave 0.085 g of title compound. 1H NMR (CD3OD) δ(major rotamer) 4.63 (t, 1H, J=7 Hz), 3.73 (s, 3H), 3.55-3.7 (m, 1H), 3.0-3.5 (m,4H), 2.3-2.7 (m, 5H), 1.9-2.2 (m, 3H), 2.08 (s, 3H), 1.6-1.9 (m, 4H), 1.46 (s, 9H), 1.3-1.45 (m, 2H), 0.92-1.02 (m, 3H).

Provenance & Evidence