HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1779505Generated: November 3, 2026
Hydrochloric Acid → 3(S)-ethyl-prolyl-methionine isopropyl ester hydrochloride
https://huagongshe.com/reaction/1779505
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3(S)-ethyl-prolyl-methionine isopropyl ester | HCID 86750790 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3(S)-ethyl-prolyl-methionine isopropyl ester hydrochloride | HCID 86750791 | — |
Reaction Steps
N-(t-Butyloxy carbonyl)-pyrrolidin-2(S)-ylmethyl]3(S)-ethyl-prolyl-methionine isopropyl ester (1.38 g, 0.0028 mol) was dissolved in EtOAc (40 mL), cooled to -20° C., saturated with HCl gas, and stirred at 0° C. for 1.25 hr, and room temperature for 0.25 hr. Concentration to dryness gave pyrrolidin-2(S)-ylmethyl]-3(S)-ethyl-prolyl-methionine isopropyl ester hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05627202 |
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| Source dataset | uspto-grants-1997_05 |
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| ORD ID | ord-fc32617b41374ca8a927b0d7cf01c4a5 |
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| Source note | uspto-grants-1997_05 |
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